Mood Stabilizers

Mood stabilizers are medications used to prevent shifts in mood or "mood swings," such as depression, mania or hypomania.  They are often used to treat bipolar disorders, psychotic disorders with mood features (such as schizoaffective disorder) and certain personality disorders.


Lithium

(Eskalith, Lithobid)

Usual Daily Dosage Range:  900-1,200 mg (Maintenance) or 1,800 mg (Acute)

Possible side effects include ataxia, dysarthria, delirium, tremor, memory problems, polyuria, polydipsia, (nephrogenic diabetes insipidus), diarrhea, nausea, weight gain, euthyroid goiter or hypothyroid goiter (possibly with increased TSH and reduced thyroxine levels), acne, rash, alopecia, leukocytosis, lithium toxicity, renal impairment (interstitial nephritis), arrhythmia, cardiovascular changes, sick sinus syndrome, bradycardia, hypotension, T wave flattening and inversion, rare pseudotumor cerebri, and rare seizures.


Valproate

(Depakote, Depakene, Stavzor, Depacon)

Usual Daily Dosage Range: 1,200-1,500 mg (Mania), 500-1000 mg (Migraine), 10-60 mg/kg (Epilepsy)

Possible side effects include sedation, tremor, dizziness, ataxia, asthenia, headache, abdominal pain, nausea, vomiting, diarrhea, reduced appetite, constipation, dyspepsia, weight gain, alopecia, polycystic ovaries (controversial), hyperandrogenism, hyperinsulinemia, lipid dysregulation (controversial), decreased bone mineral density (controversial), rare hepatotoxicity with liver failure, rare pancreatitis (sometimes fatal), and rare activation or suicidal ideation and behavior.


Lamotrigine

(Lamictal, Labileno, Lamictin)

Usual Daily Dosage Range:  100-200 mg

Possible side effects include benign rash (approximately 10%), sedation, blurred or double vision, dizziness, ataxia, headache, tremor, insomnia, poor coordination, fatigue, nausea, vomiting, dyspepsia, abdominal pain, constipation, rhinitis, rare serious rash, rare multi-organ failure associated with Stevens Johnson syndrome, toxic epidermal necrolysis or drug hypersensitivity syndrome, rare blood dyscrasias, rare aseptic meningitis, rare sudden unexplained deaths have occurred in epilepsy (unknown if related to lamotrigine use), withdrawal seizures upon abrupt withdrawal, and rare activation of suicidal ideation and behavior.


Carbamazepine

(Equetro

Usual Daily Dosage Range: 400-1,200 mg

Possible side effects include sedation, dizziness, confusion, unsteadiness, headache, nausea, vomiting, diarrhea, blurred vision, benign leukopenia (transient, in up to 10%), rash, rare aplastic anemia, agranulocytosis (unusual bleeding or bruising, mouth sores, infections, fever, sore throat), rare severe dermatologic reactions (toxic epidermal necrolysis and Stevens Johnson syndrome, especially in patients with HLA-B*1502), rare induction of psychosis or mania, SIADH with hyponatremia, increased frequency of generalized convulsions (in patients with atypical absence seizures), and rare activation of suicidal ideation.


Olanzapine/ Fluoxetine

(Symbyax)

Usual Daily Dosage Range: 6-12 mg olanzapine/ 25-50 mg fluoxetine

Possible side effects include sexual dysfunction, gastrointestinal disturbances, insomnia, sedation, agitation, tremors, headache, dizziness, sweating, bruising, rare bleeding, rare activation of suicidal ideation and behavior, rare induction of mania, increased risk for diabetes mellitus and dyslipidemia, dry mouth, constipation, dyspepsia, weight gain, peripheral edema, joint pain, back pain, chest pain, extremity pain, abnormal gait, ecchymosis, tachycardia, orthostatic hypotension, rare tardive dyskinesia, rare rash on exposure to sunlight, hyperglycemia (in some cases extreme and associated with ketoacidosis or hyperosmolar coma or death), rare neuroleptic malignant syndrome, rare seizures, and increased risk of death and cerebrovascular events in elderly patients with dementia-related psychosis.


Quetiapine

(Seroquel, Seroquel XR)

Usual Daily Dosage Range: 400-800 mg

Possible side effects include increased risk for diabetes and dyslipidemia, dizziness, sedation, dry mouth, constipation, dyspepsia, abdominal pain, weight gain, tachycardia, orthostatic hypotension, theoretical risk of tardive dyskinesia, hyperglycemia (in some cases extreme and associated with ketoacidosis or hyperosmolar coma or death), rare neuroleptic malignant syndrome, rare seizures, and increased risk of death and cerebrovascular events in elderly patients with dementia-related psychosis.


Lurasidone

(Latuda)

Usual Daily Dosage Range: 40-80 mg

Possible side effects include sedation (somnolence), akathisia, nausea, may increase risk for diabetes and dyslipidemia, may cause tardive dyskinesia, hyperglycemia (in some cases extreme and associated with ketoacidosis or hyperosmolar coma or death), increased risk of death and cerebrovascular events in elderly patient with dementia-related psychosis, rare neuroleptic malignant syndrome, and rare seizures.


Aripiprazole

(Abilify)

Usual Daily Dosage Range: 15-30 mg 

Possible side effects include dizziness, insomnia, akathisia, activation, nausea, vomiting, orthostatic hypotension, constipation, headache, asthenia, sedation, theoretical risk of tardive dyskinesia, rare neuroleptic malignant syndrome, rare seizures, increased risk of death and cerebrovascular events in elderly patients with dementia-related psychosis, hyperglycemia, leukopenia, neutropenia, agranulocytosis, dysphagia, hyperthermia, tachycardia, and bradycardia.


Cariprazine

(Vraylar)

Usual Daily Dosage Range 1.5-6 mg

Possible side effects include orthostatic hypotension, dizziness, headache, restlessness, anxiety, somnolence, dizziness, fatigue, dysphagia, hyperthermia, xerostomia, blurred vision, weight gain, may increase risk for diabetes and dyslipidemia, leukopenia, neutropenia, agranulocytosis, rare tardive dyskinesia, hyperglycemia (in some cases extreme and associated with ketoacidosis or hyperosmolar coma or death), increased risk of death and cerebrovascular events in elderly patient with dementia-related psychosis, rare neuroleptic malignant syndrome, and rare seizures.


Usual daily dosage range is for adults.  The above information is meant as a general reference only and should not be used as a guideline for prescribing of medications or medical advice.  Please check the manufacturer’s product information sheet or the P.D.R. for the most accurate information, including dosage schedule, side effect profile and contraindications.  Please consult a physician for medical advice.  Brand names are registered trademarks. Disclaimer